The process of DNA replication relies on the coordinated action of a ring‐shaped sliding clamp and its specialised loader complexes. Sliding clamps, typified by proliferating cell nuclear antigen ...

Humans and baker's yeast have more in common than meets the eye, including an important mechanism that helps ensure DNA is copied correctly, reports a pair of studies. The findings visualize for the ...

Scientists have discovered that a protein once thought to simply help load a factor necessary for the copying of DNA, actually plays a key role in ensuring fast and reliable replication—an insight ...

Though scientists have learned much about DNA damage and repair over the past 50 years, important outstanding questions remain. One particularly bedeviling puzzle is how a repair protein called the ...

The DNA damage response is essential for maintaining genome integrity. When DNA damage or replication stress occurs, a checkpoint signaling pathway is activated to arrest the cell cycle and initiate ...

The clamp then closes and signals to the polymerases that they can begin replicating DNA. Using high-powered cryo-electron microscopes, Li, O'Donnell and their teams revealed previously unknown facets ...

The results of this collaborative project overturn some conventional wisdom about how the DNA repair process works. DNA is often likened to a blueprint. The particular sequence of As, Cs, Gs, and Ts ...

DNA replication is a complex process with many moving parts. In baker's yeast, the molecular complex Ctf18-RFC keeps parts of the replication machinery from falling off the DNA strand. Human cells use ...

DNA is often likened to a blueprint. The particular sequence of As, Cs, Gs, and Ts in DNA provides information for building an organism. What’s not captured by this analogy is the fact that our DNA ...