Intermediate filaments (IFs) are critical parts of the structure of cells. They are essential for both normal tissue structure and function. Enabling cells to withstand the stretch and pressure on the ...

(Nanowerk Spotlight) In animal cells, the well known cytoskeletal proteins actin microfilaments and microtubules are accompanied by a third filament system that in humans consist of a family of more ...

Living cells are constantly exposed to a wide variety of mechanical stresses: heart and lungs must withstand expansion and contraction; our skin must be resistant to tearing whilst retaining ...

Intermediate filaments may function to integrate mechanically the various structures of the cytoplasmic space in a way that is tailored to the differentiated state of the cell. The need to modulate ...

The histopathological diagnosis of malignant melanoma is typically straightforward, particularly for cases with an in situ component or pigmentation. However, many melanomas lack diagnostic ...

Just as the skeleton and muscles move the human body and hold its shape, the cells of the body are stabilized and moved by a cellular skeleton. This cellular skeleton is a dynamic structure, ...

This is a site to keep an eye on, despite the fact that (while writing this) the homepage flashed the disclaimer that the page is “currently undergoing radical software updates.” Curated by the Centre ...

Changes to the intermediate filament (IF) protein, vimentin, were found to promote tumor growth by increasing cancer stemness in an estrogen independent manner. Targeting vimentin and/or the long ...

The symptoms of neurodegenerative diseases like Alzheimer’s, frontotemporal dementia, and chronic traumatic encephalopathy (CTE) are different, but they have one feature in common: the presence of ...

Your cells aren’t just tiny blobs—they have an internal skeleton that keeps them in shape, moves things around, and even helps them adapt to change. This cytoskeleton is a dynamic network of filaments ...